November 7, 2018

Exponential Medicine, Day 4 - Cool Stuff Summary (Nov 7 2018)

INTRO / SUMMARY
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Day Four

Wednesday, November 7, 2018

Session 23: The Morning After? Politics, Policy & What Just Happened

Session 24: Augmenting Biology and Reversing Aging

24.1 Andrew Pelling Scientist & Founder, Pelling Lab

24.2 Amy Wagers PhD Professor of Stem Cell and Regenerative Biology, Harvard University

Pioneering Longevity with Peter H. Diamandis & Bob Hariri

Peter Diamandis MD Executive Founder and Director, Singularity University, Founder and Executive Chairman, XPRIZE Foundation

Bob Hariri, MD, MPH Founder, Chairman & CEO, Celularity

David Karow MD PhD CEO, Human Longevity Inc

Osman Kibar PhD CEO, Samumed

Art and Medicine with Andrew Paul Leonard

Session 26: Crystal Ball: Creating the Future of Healthcare

Janet Foutty Chair and CEO, Deloitte Consulting

Doug Beaudoin Principal, Life Sciences & Healthcare, Deloitte

Pat Combes Worldwide Technical Leader, Healthcare & Life Sciences, Amazon Web Services

Diane Hammon Vice President and Chief Strategy Officer, Moffitt Cancer Center

Session 27: Democratizing Technology for Global Health

David Bray PhD Impact & Disruption Faculty, Singularity University, Executive Director, People-Centered Internet, President, Hu-manity.org

Peter M. Small, MD Rockefeller Fellow

Alex Kumar MBBS Global Health Physician, NHS National Institute for Health Research

Ralph Simon FSRA Chief Executive, Mobilium Global

Session 28: Converting Insights into Action: What Happened at xMed. What Does This Mean? What's Next?

Tom Wujec Founder, The Wujec Group

Will Weisman Executive Director, Summits, Singularity University

Daniel Kraft MD Faculty Chair for Medicine, Singularity University and Founder & Chair, Exponential Medicine

Session 23
The Morning After? Politics, Policy & What Just Happened

Peter:

Intellectual property and capital does not respect political boundaries.

Where you start your company may be influenced by the political and legal surroundings. We don’t want to run good companies out of the country.

Education of children:

  • Very little of what is in current education is unusable in real life
  • Critically important to help children find their passion
  • Important to help people ask great questions…because now finding the answer may be easier than knowing what the right question is to ask.
  • Grit - persistance

Session 24
Augmenting Biology and Reversing Aging

24.1  Andrew Pelling

Scientist & Founder, Pelling Lab

Field of mechanobiology - how do cells sense, and generate their own mechanical forces. The genome can be regulated by physical features (eg. stretch). Every stage of development of an embryo can be influenced by mechanical forces.

There is an important relationship between the physical world and how the genome is expressed. If we focus just on the DNA part, we actually loose an important part of the picture.

However, exactly what the relationship between physical world and genome expression is, remains to be discovered.

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At rest cells are naturally undergoing certain amounts of stretch.

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cellular In some of their experiments the behaviour of cells dramatically changes - they become aggressively metastatic - when stretch is introduced into cellular model.

How do cells sense shape? Yes, they spatially pattern over areas

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How can we create bio-scafolds, that may be used for regenerative medicine and tissue engineering? Can we use a material such as ‘plans’ as the bio-scafold?

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Experiment involved taking piece of apple, stripping out all the cells (decellularization), and one is left only with the extracellular matrix. Surpassingly, when cells were applied, they grew in it well.

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Bough apples, carved them into shape of ears. Decellularization process. And grew human cells on them.  Below early image of scafold.

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Question - are the materials safe in a body? They placed the human-cell-apple-scafold after it had been cultured into a mouse, and under the microscope health innervation of mouse cells and blood vessels was seen.

Note: no stem cells. No growth factors.

Lab’s focus at this time: bone, soft tissue cartilage, spinal cord and nerve repair

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His lab:  be curious, be rigorous, have a diverse group of people

24.2  Amy Wagers

PhD Professor of Stem Cell and Regenerative Biology, Harvard University

Uses technique of Parabiosis - which is joining together (aka side/by/side) mice. Join together young/young, young/old, and old/old combinations. Can see the effect of having old/young cells on how they influence each other.

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Changes in different cell markers and predict outcomes, and modulation of them can effect lifespans.

Specifically GDF11

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Pioneering Longevity with Peter H. Diamandis & Bob Hariri

Peter Diamandis

MD Executive Founder and Director, Singularity University, Founder and Executive Chairman, XPRIZE Foundation

“The comment, I don’t want to know what’s going on inside my body, is bullshit”

‘If we can add an extra 10 to 20 years of productive lifespan, that influences government, and society dramatically’

Bob Hariri

MD, MPH Founder, Chairman & CEO, Celularity

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Health concerns of aging including: chronic diseases, frailty and loss of activities of daily living, cognitive decline.  

Placenta cells do not need to be matched to the individual, and they do not induce a rejection response.


David Karow

MD PhD CEO, Human Longevity Inc

3000 people total have gone through Health Nucleus.

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Dramatic drop in the cost since opening in 2015.   Current cost is $5,000 for first visit, and $3000 for subsequent. [Which is below the actual cost]

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Osman Kibar

PhD CEO, Samumed

$13 billion dollar private company.

Restorative Medicine company. [Doing out of this world work.]

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Repair the Wnt pathway.

Examples - note: these are in human clinical trials

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Also have program to regenerate hair, remove wrinkles, to remove scarring in the lungs (fibrosis). [These are all in human clinical trials].

It’s a spare parts business. You replace the part that is worn out.

The cartilage cells in the knee is different than cartilage cells nose. This means they are aware of their local surroundings and exactly what type of cartilage they are to develop.

They have dosed over 1000 patients, and have not noticed a single adverse drug event. The drug is designed that it is inert of the Wht pathway is intact.

It is not just about anti-aging - because that is only stoping aging. They are de-aging, because they are able to reverse the aging process.

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How is this done?

Embryonic stem cells  -> progenitor stem cells -> adult cells

The embryonic stem cells only function inside the fetus/embryo

The Progenitor stem cells (eg. dermal stem cells, epithelial stem cells, mesenchymal stem cells), remain in the body tissues, and replenish our adult cells (eg. bone, cartilage, hair, skin, etc) as we live.

The Wnt pathway regulates the differentiation from progenitor to adult stem cells.

Note: the Wnt pathway is the same across all animal species.

As we age, the Wnt pathway becomes out of balance, and this leads to under/over production of adult cells leading to disease and aging.

They develop drugs they move the Wnt levels into the healthy range for that adult cell type.

Daniel Kraft

MarrowMiner

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Art and Medicine

with Andrew Paul Leonard

Session 26
Crystal Ball: Creating the Future of Healthcare

Janet Foutty  Chair and CEO, Deloitte Consulting

Doug Beaudoin Principal, Life Sciences & Healthcare, Deloitte

Pat Combes Worldwide Technical Leader, Healthcare & Life Sciences, Amazon Web Services

Diane Hammon  Vice President and Chief Strategy Officer, Moffitt Cancer Center

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Session 27
Democratizing Technology for Global Health

Ralph Simon

FSRA Chief Executive, Mobilium Global

Peter M. Small

MD Rockefeller Fellow

The global health mafia will not disrupt itself.

Alex Kumar

MBBS Global Health Physician, NHS National Institute for Health Research

Global Health Security Agenda

  • Antimicrobial resistance (AMR)
  • Water and food scarcity
  • Climate Change
  • Outbreaks
  • homo sapiens

David Bray

PhD Impact & Disruption Faculty, Singularity University, Executive Director, People-Centered Internet, President, Hu-manity.org

Personalized medicine can also be personalized poison.

We may be living in an area where we move from being organized by geography, to being organized by networks.

When we are organized by geography ideas have a bell curve with opposite positions on either side.

When organized by networks, like forms with like, and we get amplification of extremes and loss of the middle.

Session 28:
Converting Insights into Action:
What Happened at xMed. What Does This Mean? What's Next?

Tom Wujec Founder, The Wujec Group

Will Weisman Executive Director, Summits, Singularity University

Daniel Kraft MD Faculty Chair for Medicine, Singularity University and Founder & Chair, Exponential Medicine

All slides are from the Singularity University’s Exponential Medicine Conference YouTube live stream November 7, 2018.

Watch past Singularity University videos on their channel.

To register for next year’s conference, please visit their website, https://exponential.singularityu.org/medicine/  It sells outs, so register early.

You may be interested in the Notes from Day 1, or Notes from Day 2, Notes from Day 3,

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